Validation of the Osteomyelitis Induced by Methicillin-Resistant Staphylococcus aureus (MRSA) on Rat Model with Calvaria Defect

Background@#Osteomyelitis resulting from bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA) that are resistant to multiple drugs, brings further clinical challenges. There is currently no model of osteomyelitis induced by MRSA using rats with calvaria defects. So, We induced osteomyelitis in rat models with the calvaria bone defect. @*Methods@#The rats were randomly divided into six groups according to inoculation dose levels, which ranged from 6 × 100 to 6 × 105 CFU/5 µl. Bone tissues were retrieved from all rats used in the study and assessed using histology, microbiology, and radiobiology 4 weeks after surgery to evaluate the relationship between inoculation dose and infectivity. @*Results@#In Histological results, high levels of inflammatory responses, bone necrosis, and bacteria were observed in treatment groups G3 to G5. In IHC staining, high levels of cox-2 expression were observed in treatment groups G3. Microbiological observations also indicated that significantly higher numbers of CFUs were found in G3 to G5. In radiography results, the bone mineral density in G3 to G5 was significantly higher than in the control group, G1, and G2. Our results indicate that an inoculating dose of 6 × 103 CFU/5 μl is sufficient to induce the development of osteomyelitis in rat models. @*Conclusion@#This study suggests that the minimum dose (6 × 103CFU/5 µl) can induce osteomyelitis in calvaria rat model. This can offer information and ability of more accurately modeling osteomyelitis and simulating the challenge of osteomyelitis treat.

Validation of the Osteomyelitis Induced by Methicillin-Resistant Staphylococcus aureus (MRSA) on Rat Model with Calvaria Defect

Background@#Osteomyelitis resulting from bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA) that are resistant to multiple drugs, brings further clinical challenges. There is currently no model of osteomyelitis induced by MRSA using rats with calvaria defects. So, We induced osteomyelitis in rat models with the calvaria bone defect. @*Methods@#The rats were randomly divided into six groups according to inoculation dose levels, which ranged from 6 × 100 to 6 × 105 CFU/5 µl. Bone tissues were retrieved from all rats used in the study and assessed using histology, microbiology, and radiobiology 4 weeks after surgery to evaluate the relationship between inoculation dose and infectivity. @*Results@#In Histological results, high levels of inflammatory responses, bone necrosis, and bacteria were observed in treatment groups G3 to G5. In IHC staining, high levels of cox-2 expression were observed in treatment groups G3. Microbiological observations also indicated that significantly higher numbers of CFUs were found in G3 to G5. In radiography results, the bone mineral density in G3 to G5 was significantly higher than in the control group, G1, and G2. Our results indicate that an inoculating dose of 6 × 103 CFU/5 μl is sufficient to induce the development of osteomyelitis in rat models. @*Conclusion@#This study suggests that the minimum dose (6 × 103CFU/5 µl) can induce osteomyelitis in calvaria rat model. This can offer information and ability of more accurately modeling osteomyelitis and simulating the challenge of osteomyelitis treat.

Current Concepts in the Articular Cartilage Repair

Articular cartilage defects are common in orthopedic practice. Most clinical and research efforts focus on restoring the damaged cartilage in connection with osteoarthritis or trauma. This article explains the current clinical approaches for repairing cartilage, as well as the research approaches and those under translation into clinical practice. Tissue engineering techniques are being employed with aims of repopulating a cartilage defect with hyaline cartilage containing living chondrocytes with hopes of improving the clinical outcomes. Cartilage tissue engineering involves the cell source, biomaterial and membranes, and growth stimulators. Tissue engineering is being applied to clinical medicine by autologous chondrocyte implantation or similar techniques. While basic science has refined orthopedic treatment of chondral lesions, available evidence does not conclude the superiority of tissue engineering methods over other techniques in improving the clinical symptoms or restoring the native joint mechanics.

Vaccination for Athletes: Evidence and Recommendations / 대한스포츠의학회지

As interest in sports rapidly grows in Korea, fostering of elite athletes and preservation of the athletic ability no longer became the task of advanced countries only. In that aspect, health of athletes and their associated coaches, athlete trainers, team members such as team doctors, and even their families is certainly a matter of concern. Especially when it comes to the inoculation of infectious disease prevention, it needs to be considered as one of the most economical and effective ways to promote health in sports people as well as elite athletes. The purpose of this article is to go over the specific circumstances of the athletes and related literatures on vaccination. In addition, we provide recommendations on the vaccination of athletes regarding the actual situation of sports in Korea.

Arthroscopic Modified Broström Operation for Lateral Ankle Instability / 대한정형외과학회잡지

Lateral ankle sprain is the most common ankle injuries. Patients who fail conservative treatments are candidates for modified Broström operation (MBO). Traditionally, the primary surgical treatment performed is the open MBO. Recently, there has been an evolution in the arthroscopic treatment of lateral ankle injury. Several reports reveal biomechanically equivalent results of arthroscopic vs . open MBO when using matched cadaver pairs. Also there was no difference in the clinical or radiologic outcomes between the arthroscopic and open MBO in randomized controlled trial. Therefore, arthroscopic MBO is reasonable and good alternative treatment for lateral ankle injury. Actually new techniques of arthroscopic treatment for ankle injury is introduced about arthroscopic syndesmotic repair and arthroscopic deltoid repair. Arthroscopic techniques for ankle injuries seem to develop further in the future.

Early Transformed Diabetic Foot Ulcer into a Malignancy: A Case Report / 대한족부족관절학회지

This paper presents a case of an early malignant transformation of untreated ulcers in a patient with diabetes. This case shows that Marjolin's ulcer can occur not only after chronic injury, but can also develop in the early stages after the onset. Hence, an early biopsy for diabetic foot ulcers that fail to heal with acute treatment can enable an earlier diagnosis and treatment without amputation, resulting in a better quality of life for the patient.

Treatment of Osteochondral Lesions of the Talus in Athletes / 대한스포츠의학회지

The definition of osteochondral lesion of the talus (OLT) is any defect involving both the articular surface and the subchondral bone of the talus. Many of these lesions are associated with acute ankle injury. Although many classification schemes for OLT have been proposed, Berndt and Harty's 4-staging classification is most commonly used. Stage 4 lesions and symptomatic lesions under grade 3 are usually recommended to surgical treatment. The treatment approach for athletes should be more elaborate due to the need for an early return to play. Several different types of treatment are described for OLTs in athletes, including bone marrow stimulation, osteochondral autograft transfer system, and autogenous chondrocyte implantation. Osteochondral autograft transfer system shows good clinical outcome and has the advantages that could be applied to large defect and recurred lesions, however, it has some disadvantages in terms of the complications related with the donor site and the difficult approach to the medial lesions. Although autogenous chondrocyte implantation has been extensively applied for treating OLTs with successful clinical outcomes, it has some limitations that apply to athletes in terms of the 2-stage and complicated procedure and the insurance issues. Bone marrow stimulation being a simple and cost-effective procedure associated with a low complication rate and low postoperative pain has faster return to play and is recommended the first-line treatment for the OLTs of athletes.

The Surgical Outcome of Tibiotalocalcaneal Arthrodesis Using a Retrograde Intramedullary Nail / 대한족부족관절학회지

PURPOSE: Tibiotalocalcaneal arthrodesis has been used as a treatment option for severe deformity including Charcot arthropathy, avascular necrosis of the talus, and severe osteoarthritis of the ankle and subtalar joint. The purpose of this study was to evaluate the result of the surgical outcome of tibiotalocalcaneal arthrodesis using a retrograde intramedullary nail. MATERIALS AND METHODS: Tibiotalocalcaneal arthrodesis using a retrograde intramedullary nail was performed by one surgeon in 36 cases. Clinical and radiological finding was evaluated using assessment of fusion time, 5th metatarsal-tibial angle, possibility of postoperative complication, visual analogue scale for pain and American Orthopaedic Foot and Ankle Society (AOFAS) score. RESULTS: Union was achieved in 33 cases at an average of 23 weeks (11~29 weeks). There were 3 cases of nonunion and 1 case of reoperation. Nail-tibial angle tended to be larger in nonunion cases. AOFAS score showed significantly poor outcome at malalignment (> or =5degrees), negative value of 5th metatarsal-tibial angle. CONCLUSION: Tibiotalocalcaneal arthrodesis using a retrograde intramedullary nail is considered a useful treatment option for severe destruction and deformity involving ankle and subtalar joint.

Distal Radius Fractures Using Acu-Loc Volar Plate

OBJECTIVE: We determined the radiographic outcome of distal radius fractures with Acu-loc volar plate. METHODS: Forty-one patients were recruited between August 2009 and September 2010. There were 10 males and 31 females, with a mean age 61.2. Fractures were radiologically classification the Frykman. Fifteen fractures were group 8, eight were group 7, ten were group 6, four were group 5 and four were group 3. Distal part of the fractures was dorsally inclined in 37 wrists and inclined to volar side in four wrists. Lateral and anteroposterior radiographs taken after operated day, the fracture were compared with radiographs of the injured wrist and the differences in palmar tilt, ulnar variance; radial height; radial shift and radial inclination were measured. RESULTS: There was significant improvement in the measurements of radial height, radial inclination, volar tilt, ulnar variance and radial shift postoperatively. The radial height improved from an average of 8.5 mm (range, 3 to 15 mm) to 11.0 mm (range, 8 to 15 mm), the radial inclination improved from an average of 21.5 degree (range, 10 to 40 degree) to 28.1 degree (range, 19 to 44 degree), the palma tilt improved from an average of 12.9 degree (range, 6 to 22 degree) to 17.2 degree (range, 7 to 27 degree), the ulnar variance improved from an average of -2.3 mm (range, -6 to 4 mm) to 1 mm (range, -3 to 7 mm) and the radial shift improved from an average of 18.7 mm (range, 15 to 26 mm) to 17.3 mm (range, 12 to 21 mm). CONCLUSION: Acu-loc volar plate is a safe and effective device.

Results of Osteoporotic Treatment Drug after Periarticular Fracture of Hip

PURPOSE: The Purpose of the study is to know patients' compliance of drug treatment of osteoporosis after operation of fracture and to compare of accompanying fractures between patients who diagnosed with osteoporosis itself and had the drug treatment of osteoporosis after surgery of periarticular fracture of hip. MATERIALS AND METHODS: In experimental group, consecutive 60 patients who had fracture of femoral neck and trochanter. And in control group, 61 patients diagnosed osteoporosis with drug treatment within the same period in orthopedic department from July 2006 to July 2007. The average age is 73.8 (+/-6.7) year in experimental group, and 66.6 (+/-7.46) year in control group. Both groups had at least a year follow-up with drug treatment and had BMD again at least a year later. RESULTS: BMD test in experimental group showed -3.05 (+/-1.35) preoperatively and -2.74 (+/-1.50) in last follow-up. BMD test in control group showed -3.55 (+/-0.52) in initial administration and -3.10 (+/-0.87) in last follow-up. The results showed a significant improvement in statistical analysis (p=0.0002, p<0.0001). CONCLUSION: The compliance of drug treatment of osteoporosis after operation of periarticular fracture of hip is the same as in patients' diagnosed osteoporosis.

The Talus-1st Metatarsal Angle, the Talo-Horizontal Angle and Calcaneal Pitch Angle of Young Men in Korea / 대한족부족관절학회지

PURPOSE: The purpose of this study is to find out the normal angles of the talus-1st metatarsal angle, the talo-horizontal angle and calcaneal pitch angle for diagnosis of foot deformity in Korea. This would be helpful as it would provide a basic angular measurement of flat and cavus foot that indicates the need for operation. MATERIALS AND METHODS: Within a period of four months from January 2007 to April 2007, We have established 600 feet of 300 males without trauma history of foot. The source to image distance is 40 inches and erect weight bearing radiographs are obtained in anteroposterior and lateral projections. The significant angular measurements that define flat or cavus foot are the talus-1st metatarsal angle, the talo-horizontal angle and calcaneal pitch angle. RESULTS: The mean age was 21 years (19-22 years) old. The mean talus-1st metatarsal angle was 0+/-6.9degrees, the mean talo-horizontal angle was 25.8+/-4.5degrees and the mean calcaneal pitch angle was 23.9+/-5.1degrees. CONCLUSION: We can consider that mean talus-1st metatarsal angle, talo-horizontal angle and calcaneal pitch angle are 0+/-6.9degrees, 25.8+/-4.5degrees and 23.9+/-5.1degrees as an normal angle limit of young age in Korea.

The 4th-5th Intermetatarsal Angle and the 5th Metatarsophalangeal Angle of Young Men in Korea / 대한족부족관절학회지

PURPOSE: The purpose of this study is to find out the normal angles of forefoot for diagnosis of bunionette deformity in Korea. This would be helpful as it would provide a basic angular measurement of bunionette deformity that indicates the need for operation. MATERIALS AND METHODS:Within a period of four months from January 2007 to April 2007. We have established 300 males and 600 feet without trauma history of foot. The source to image distance is 40 inches and erect weight bearing radiographs are obtained in anteroposterior and lateral projections. The significant angular measurements that define a bunionette deformity are the fourth-fifth intermetatarsal angle, the fifth metatarsophalangeal angle RESULTS:The mean age was 21 years(19-22 years) old. The mean 4th-5th intermetatarsal angle was 9.4+/-4.7 degrees , the mean 5th metatarsophalangeal angle was 7.9+/-9.2 degrees . CONCLUSION: We can consider over the 14.1 degrees on the 4th-5th intermetatarsal angle and over 17.1 degrees on the 5th metatarsophalangeal angle as an operational indication.

Efficacy of Physiotherapist after Total Knee Arthroplasty

PURPOSE: The range of motion (ROM) of the knee and the satisfaction rate after total knee arthroplasty are the most important factors when evaluating the result of an operation. The purpose of this study was to determine whether the ROM and the functional outcome of these patients increase after joint exercise that is performed by special physiotherapists. MATERIALS AND METHODS: 200 cases of 120 patients, who underwent total knee replacement arthroplasty for osteoarthritis between August 2006 and May 2008, were enrolled in this study. These cases were randomly divided into 3 groups. Only CPM (continuous passive movement) and MSE (muscle strengthening exercise) were performed after KTA in the first group. In the second group, pROME was performed by physical therapists in our rehabilitation institution during the hospital stay, as well as CPM and MSE. CPM, MSE and pROME were performed by special physiotherapists during the hospital stay and also in the outpatient department after being discharged from the hospital in the third group. We compared the results of these groups. RESULTS: The range of motion was not increased among the groups. On the other hand, the third group showed a significantly higher functional outcome, as compared to that of the first and second groups. Conclusion: Although the range of motion of the knee joint was not increased enough to achieve statistical significance, the functional outcome showed significant increases with the pROME performed by physiotherapists. This result demonstrates that the knee exercises performed by special physiotherapists are useful and they can yield good outcomes in patients who underwent TKA.

Traumatic Dynamic Hallux Varus: A Case Report / 대한족부족관절학회지

The first metatarsophalangeal joint injury is common in professional soldiers and athletes. But this was rarely reported. A professional soldier has varus instability in the first metatarsophalangeal joint due to hyperextension. In the MR Imaging, weavy appearance in lateral collateral ligament and high signal change in plantar plate was shown. So he has surgical treatment using reconstructive procedure. At first, 4th extensor digitorum longus tendon was splitted longitudinally and harvested, second triangular shape reconstruction on lateral joint line was done using harvested tendon. One year later, fifteen degrees was limited compared with intact side. Reconstruction using 4th extensor digitorum longus tendon in traumatic dynamic hallux varus was good method.

Complications after Total Ankle Replacement Arthroplasty / 대한족부족관절학회지

PURPOSE: We evaluated the complications and failures after total ankle arthroplasty during at least 2 years short term follow up. MATERIALS AND METHODS: There were 45 cases of 42 patients of HINTEGRA(R) (Newdeal SA, Lyon, France) model from November 2004 to August 2006. Follow up averaged at least 2 year. We evaluated the complications and analyzed the cause of the failures. RESULTS: There were totally 15 cases of complication, 5 cases of medial impingement syndrome, 3 cases of varus malposition, 2 cases of delayed healing of wounds, and each one case of deep peroneal nerve problem, medial malleolus fracture, post-operative deep infection, gouty arthritis pain, and Achilles tendinitis. CONCLUSION: Total ankle arthroplasty had higher complication rate than any other joint arthroplasty, so we need a more meticulous preoperative and peri-operative care.

Results in Conservative Treatment of Osteochondral Lesion of Talus / 대한족부족관절학회지

PURPOSE: The purpose of this study is to determine the results of conservative treatment of osteochondral lesion of talus (OLT). This study would be helpful to determine the treatment methods for OLT patients. MATERIALS AND METHODS: We have established 69 cases of osteochondral lesion of talus, from December 2004 to June 2006 in a period of 18 months. Symptoms were confirmed through survey and a medical examination by interviewing patients. Diagnosis was made through physical examination, simple radiography and MRI. AOFAS score of all the patients were measured. When the patients did not get improved with conservative treatment, surgical operation was done. RESULTS: 27 out of the 69 patients were treated using conservative treatment. Initial AOFAS scored was 66.37+/-8.89 points. After treatment, AOFAS scores had increased to 83.78+/-8.48 points. In cases of surgery, AOFAS scores had increased from 64.17+/-13.43 points preoperatively to 80.45+/-8.67 points. CONCLUSION: 60% of conservative treatment was useless in treating OLT patients. Surgical operation is still needed to be performed. Therefore, treatment should be done with sufficient understanding of the results.

Stress Fracture in Medial Malleolus in Ankle (A Case Report) / 대한족부족관절학회지

Although stress fracture of lower extremity is a relatively common, stress fracture of medial malleolus is rare. So we report one case. He is a 17 year old soccer player and successfully treated with surgical treatment (open reduction and internal fixation with one screw.

Results in Stress Test in the Ankle Stability of Young Men in Korea / 대한족부족관절학회지

PURPOSE: The purpose of this study is to find out the normal results in ankle on varus stress, valgus stress, and anterior draw stress in young men in korea. This would be helpful as the basic data of measuring of ankle instability for operational indication. MATERIALS AND METHODS: Varus and Valgus stress anteroposterior radiographs and Anterior drawing stress lateral radiographs of 600 normal ankles were reviewed. First, A line parallel was drawn parallel to the articular surface of the distal tibia, and another line was drawn parallel to the articular surface of the talus on anteroposterior radiographs. The interior angle that subtended by these two lines was measured. Second, the reference point is located at the posterior border of the tibia, and the shortest distance from this point to the proximal posterior articular surface of the talus is measured. RESULTS: There were 300 males and 600 ankles. The mean age overall was 21 years (19-22 years) old. The mean length of ankle on anterior draw stress was 5.54+/-3.33 mm. The mean a interior angle of ankle on varus stress was 0degrees-8.93degrees, and on valgus stress 0degrees-7.78degrees. CONCLUSION: We can consider for operational indication at over the 8.87 mm on anterior draw stress, over the 8.93degrees on varus stress, and over the 7.78degrees on valgus.

Surgical Result of the Os Trigonum Syndrome / 대한족부족관절학회지

PURPOSE: The purpose of this study is to find out the clinical results of excision of the Os trigonum through a posterolateral approach and to compare the surgical results of athletes with non-athletes. MATERIALS AND METHODS: Within a five year and four month period, from July 2001 to October 2006, twenty patients underwent excision of symptomatic os trigonum, with a mean age of 22 years and 9 months at the time of the operation. There were fifteen female patients and five male patients. Eight were athletes and twelve were non-athletes. RESULTS: The average duration of postoperative follow-up was thirty months. The postoperative AOFAS scored an average of 89 points compared to the preoperative AOFAS scored an average of 67 points. Sixteen patients (80%) who were operated, had good or excellent satisfactory results. The average preoperative AOFAS score of the athletes were 61 points, compared to the average postoperative AOFAS score of 90 points. For non-athletes, the average preoperative score was 71 points, compared to the average postoperative AOFAS score of 88 points. Seven athletes (87%) and nine non-athletes (75%) had good or excellent satisfaction results after surgery. The time until full recovery averaged 88 days for all the patients. 133 days for the athletes and 56 days for the non-athletes. There is no analytic difference between result in athletes and result in non-athletes. CONCLUSION: Open surgical treatment through posterolateral approach of os trigonum syndrome of the ankle may be effective modality regardless of the patient being an athlete or non-athlete.

Proximal Metatarsal Chevron Osteotomy for Moderate to Severe Hallux Valgus: A Mean Eight Year Follow up / 대한족부족관절학회지

PURPOSE: The purpose of the present study is to evaluate the proximal metatarsal chevron osteotomy outcomes for moderate to severe hallux valgus more than seven year follow up. MATERIALS AND METHODS: Between 1996 and 1998, hallux valgus 61 cases were evaluated. The follow up period was more than seven years. The clinical review analyzed by the hallux metatarsophalangeal-interphalangeal scale of the American Orthopedic Foot and Ankle Society, radiologic review by the hallux valgus angle, first and second intermetatarsal angle. Complication also evaluated. RESULTS: Clinically, preoperative AOFAS score was average 43 points (range; 16~60 points) which significantly improved to 88 points (range; 61~100 points) at last follow up periods. Radiologically, the mean preoperative, postoperative, last follow up hallux valgus angle was 34 degrees, 5.2 degrees, 10.9 degrees. The mean preoperative, postoperative, last follow up intermetatarsal angle was 15.3 degrees, 3.3 degrees, 5.3 degrees. Postoperative angle change were no statistical significance (p>0.05). Complication were hallux varus 6 cases, metatarsophalangeal joint arthritis 2 cases, recurrence 1 case. CONCLUSION: Proximal metatarsal chevron osteotomy shows satisfactory outcome for moderate to severe hallux valgus more than seven year follow up.